Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs

Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects. Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired. This medication may be available under multiple brand names and/or in several different forms.

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  • Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.
  • It works by blocking pain sensations that are sent to your brain.
  • Cyclobenzaprine is used short-term to treat muscle spasms.
  • The acute oral LD50 of FLEXERIL is approximately 338 and 425 mg/kg in mice and rats, respectively.

Cyclobenzaprine is in a class of medications called skeletal muscle relaxants. It works by acting in the brain and nervous system to allow the muscles to relax. Each addiction treatment facility is different, so a person seeking treatment for Flexeril and alcohol addiction should ask to be referred to the right facility for the best chance at sustained recovery. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.

If you experience any of the following symptoms, call your doctor immediately:

The plasma concentration of cyclobenzaprine is increased in the elderly (see CLINICAL PHARMACOLOGY, Pharmacokinetics, Elderly). The elderly may also be more at risk for CNS adverse events such as hallucinations and confusion, cardiac events resulting in falls or other sequelae, drug-drug and drug-disease interactions. For these reasons, in the elderly, cyclobenzaprine should be used only if clearly needed. In such patients FLEXERIL should be initiated with a 5 mg dose and titrated slowly upward. Serotonin syndrome is an often severe, potentially life-threatening adverse drug reaction that may result from inadvertent interactions between drugs with serotoninergic activity (1).

The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. The dosage is based on your medical condition and response to treatment. This medication should only be used short-term (for 3 weeks or less) unless directed by your doctor.

Serotonin syndrome is a potentially lethal adverse drug reaction that may occur in patients taking proserotoninergic medications. Drug interactions are often responsible for the causation of this syndrome. In both cases, symptoms of autonomic instability and severe agitation started within hours of initiation of cyclobenzaprine and fully resolved within 3 days after discontinuing the proserotoninergic drugs. Drug interactions may change how your medications work or increase your risk for serious side effects.

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication. Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, constipation, or trouble urinating.

Cyclobenzaprine side effects

It works by relaxing your muscles, which reduces muscle stiffness. It belongs to a group of medications called muscle relaxants. The incidence of drowsiness, the most frequent adverse reaction, was similar with both drugs. The overall incidence of adverse reactions among patients in the surveillance program was less than the incidence in the controlled clinical studies. Upon reviewing the medication list, it became clear that the patient had been given cyclobenzaprine (10 mg three times per day) very shortly before the onset of his confusion. Cyclobenzaprine and duloxetine were stopped, and cyproheptadine (8 mg via nasogastric tube every 6 h), a serotonin antagonist, was administered for 72 h.

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Posted: Fri, 06 May 2022 18:58:57 GMT [source]

Lastly, combining and using the two together results in a far higher risk and the likelihood of any related side effects as well as a physiological or physical dependency and Cyclobenzaprine abuse. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, flexeril.live or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some medicines can interact with cyclobenzaprine and cause a serious condition called serotonin syndrome. Ask your doctor before making any changes in how or when you take your medications.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Cyclobenzaprine HCl relieves skeletal muscle spasm of local origin without interfering with muscle function. It is ineffective in muscle spasm due to central nervous system disease.

We postulate that serotonin overactivity resulted from the interaction of this drug with proserotoninergic medications already in use, phenelzine in one case and duloxetine in the other. Using cannabis with cyclobenzaprine (Flexeril) may increase side effects such as dizziness, drowsiness, impaired thinking, confusion, and difficulty concentrating. Common side effects of cyclobenzaprine include headache, tiredness, dizziness, and dry mouth, and these adverse effects may increase in likelihood and severity by using cannabis. When taken at higher doses, such as 30 to 50 mg, individuals have said that they feel as if they are floating outside their own bodies. It seems that everyone is affected differently, so some may grow tolerance and become addicted, and others may feel other effects. Some may find that the drug brings them down or makes their body feel heavy.


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